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TB-500 (Thymosin Beta-4 fragment) has been investigated for its role in actin polymerization dynamics it sequesters G-actin monomers, regulating cytoskeletal organization critical for cell migration

It was administered (50 mg/kg) to a Sprague-Dawley rat, and after 14 days of treatment, the radioiodine uptake decreased significantly, indicating that quercetin may act as a thyroid disruptor (129, 135)