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Duration of Deficiency: Chronic deficiencies may require more extended treatment to replenish depleted stores

[152] demonstrated that hyaluronic acid-modified verapamil-loaded CQDs, exhibited enhanced neuronal uptake and neuroprotective efficacy in an in vitro amyloid-induced neurotoxicity model, suggesting transporter-mediated BBB translocation and enhanced intracellular drug distribution [152]

It also found no adequate acute, repeat-dose, genotoxicity, reproductive-toxicity or carcinogenicity programme

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