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Description

Rhythm of fetoplacental 11-hydroxysteroid dehydrogenase type 2 fetal protection from morning maternal glucocorticoids

These outcomes were evaluated to determine the overall protective efficacy of marmelosin against HFD/STZ-induced diabetic alterations

Methods: SACRED is a phase III, prospective, multi-center, double-blind clinical trial (NCT03654053) that enrolled patients with compensated cirrhosis and clinically significant portal hypertension (CSPH), stratified upon concomitant use of nonselective beta-blockers, randomized enrollees 1:1 to simvastatin 40 mg/day versus placebo for up to 24 months at 11 Veterans Affairs Medical Centers in the United States