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In this way, MDM2 enables the development of tumours that retain wild-type p53

Eur J Medicinal Chem Rep

Moreover, another antifungal agent, clotrimazole, can inhibit cancer cell division and proliferation by blocking the entry of calcium and potassium ions into the cells ( The third-generation EGFR inhibitor osimertinib (OSI) has a dual function

Ethics statement and experimental models All experiments with animals were carried out according to the principles of conduct of the Brazilian Guide of Practices for the Care and Use of Animals for Scientific and Didactic Purposes of CONSEA ( Animal experimentation protocols were approved by the Committee on Ethics in the Use of Animals (CEUA) of Fundao Oswaldo Cruz (CEUA protocol LW25/20) and the Universidade de So Paulo (CEUA protocol 105/2020)

10.1016/j.mce.2003.12.006 59