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Zebrafish macrophages have previously been shown to be required for inflammatory lymphangiogenesis and expression of pro-angiogenic VEGF ligands (83)

Many of them converge on the target of rapamycin (TOR) kinase ( Figure 6A ), a main factor in determining rates of protein turnover and metabolism (Wullschleger et al., 2006)

Through physical interaction with the latter, FOXO3 prevents NFkB from undergoing nuclear translocation, and thus attenuates NF-kB-mediated pro-inflammatory response 72

As a result, direct oral GSH administration does not result in significant systemic elevation of GSH levels, curbing its utility in treating neurodegenerative diseases

The collision of replication forks with immobilised topoisomerase 1, which can be trapped on the DNA by camptothecin (CPT), triggers the phosphorylation of the DNA damage checkpoint kinase Chk1 at serine 345 by Rad3 26