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Aging is accompanied by BBB breakdown, and instead of being region-specific as in neurological diseases (e.g., hippocampus in Alzheimers disease), it is zonation-specific (capillaries are more affected than other vessel types) (Zhao et al., 2020)

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People with known hypersensitivity to cobalt or cyanocobalamin should not use cyanocobalamin injection unless a clinician has evaluated the risk and chosen an appropriate plan

In a study to assess the effects of multiple doses of sildenafil on mortality in adults with PAH (StudyA1481324), the lower dose 5 mg TID group showed a higher observed number of deaths (all related to underlying disease/disease under study), serious adverse events, and severe adverse events than the 20 mg and 80 mg TID groups [see Clinical Studies (14)]