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eNAMPT also seems to play a role in several types of infections like sepsis (167, 168) or intrauterine infection (chorioamnionitis) (169), and in autoimmune inflammatory diseases including psoriasis (170), rheumatoid arthritis (RA) (171) Crohn's disease (CD) and ulcerative colitis (UC) (172)

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Importantly, this implies that FSP1 may be essential not only in cancer resistance to ferroptosis but also in physiological contexts such as adipose tissue metabolism, where regulation of neutral lipid oxidation is critical for maintaining tissue homeostasis