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Regular neurological and hematologic assessments are crucial, as subacute combined degeneration of the spinal cord can develop gradually even after blood parameters have normalized [24]

10.1096/fj.03-0295com FASEB J

The global cognition score is weighted across the 19-test battery assessing these domains

And I think that point has to do with the intermittent challenging of yourself and whether that is through temperature changes, like cold or heat, or through other types of stressors, like physical activity or perhaps even dietary compounds that are found in plants, these are things like polyphenols or flavanols

Proc Natl Acad Sci USA 76 : 53725376