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The organoids allowed us to study the interplay between Notch, VEGF, Hippo and Wnt pathways and to show how Jagged1 haploinsufficiency results in liver fibrosis and inflammation

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Finally, the protein encoded by perR gene acts as a transcriptional repressor that controls the expression of genes involved in the response to oxidative stress (Mongkolsuk and Helmann, 2002)

doi: 10.3389/fncel.2025.1609806 Received 11 April 2025 Accepted 09 May 2025 Published 22 May 2025 Volume 19 - 2025 Edited by Hongjian Pu, University of Pittsburgh, United States Reviewed by Aniruddha Das, Cleveland Clinic, United States Karthik Dhananjayan, PSG College of Pharmacy, India Mohammed S