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Expression of Apoptosis Repressor with Caspase Recruitment Domain (ACR), An Antiapoptotic Protein, Is Strongly Prognostic in Acute Myeloid Leukemia (AML)

It appears safe up to 2,000 mg per day, but higher doses may increase TMAO

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Therapeutic strategies must therefore target the microbial ecosystem holistically rather than restricting individual amino acids, leveraging the metabolic plasticity of the gut-liver-kidney axis to shift metabolic flux toward renoprotection

Abbreviations MNPs: Micro- and nanoplastics MPs: Microplastics NPs: Nanoplastics CVDs: Cardiovascular diseases ER: Endoplasmic reticulum VSMCs: Vascular smooth muscle cells PS: Polystyrene PET: Polyethylene terephthalate PE: Polyethylene PMMA: Polymethyl methacrylate PVC: Polyvinyl chloride NH2: Amino groups COOH: Carboxyl groups PCI: Percutaneous coronary intervention FTIR: Micro-Fourier transform interferometer PyGC/MS: Pyrolysis gas chromatography/mass spectrometry MACE: Major adverse cardiovascular events EPDM: Ethylene propylene diene PP: Polypropylene PA: Polyamide LDIR: Laser direct infrared SEM: Scanning electron microscopy PU: Polyurethane cTn: Cardiac troponins CK-MB: Creatine kinase-MB ECM: Extracellular matrix ROS: Reactive oxygen species HO-1: Heme oxygenase-1 ROCK1: Rho-associated protein kinase-1 SGLT2: Sodium-glucose cotransporter 2 NOXs: NADPH oxidase eNOS: Endothelial nitric oxide synthase -SMA: smooth muscle actin SM-MHC: Smooth muscle myosin heavy chain SM22: Smooth muscle 22 tiRNAs: Transfer RNA-derived stress-induced RNAs Runx2: Runt-related transcription factor 2 ox-LDL: Oxidized lowdensity lipoprotein MDA: Malondialdehyde SODs: Superoxide dismutases GPx: Glutathione peroxidases Prx: Peroxiredoxins TLR4: Toll-like receptor 4 ATP: Adenosine triphosphate mtDNA: Mitochondrial DNA VDAC: Voltage-dependent anion channels iPSC: Induced pluripotent stem cell mPTP: Mitochondrial permeability transition pore NETs: Neutrophil extracellular traps PBMCs: Peripheral blood mononuclear cells ABS: Acrylonitrile-butadiene-styrene DAMPs: Damage-associated molecular patterns GSDMD: Gasdermin D References Wilkinson J, Hooda PS, Barker J, Barton S, Swinden J