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J Clin Endocrinol Metab 88 : 43714378 Segerlantz M et al

Research investigations commonly explore the compound in experimental models examining: NNMT enzyme interaction and inhibition dynamics Cellular metabolic signalling pathways Methylation pathway regulation Intracellular metabolic network modelling Enzyme-mediated regulatory processes Comparative enzyme inhibition research Cellular energy regulation pathways These experimental models allow scientists to investigate molecular regulatory mechanisms that influence metabolic signalling and cellular biochemical processes

Following these results, a prospective first-in-human imaging phase I study (NCT03665155) was conducted to assess [ 89 Zr]Zr-DFO-daratumumab uptake in MM patients using PET/CT