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298 Consequently, the primary goal of second-generation mTOR inhibitors is to simultaneously target both the mTORC1 and mTORC2 signaling pathways, as well as their feedback loops, which were not addressed by first-generation inhibitors

Antioxid Redox Signal 25, 119

A study has shown that ATP, produced through glycolysis, enhances the phosphorylation of STING in DCs, thereby activating the STING pathway [158] (Fig