glutathione and glutathione transdehygrogenase Synthase - an overview Glutathione Synthetase - an overview

Genes 11 , 1446 (2020)

Rausch CR, Paul S, Montalban-Bravo G, Jabbour EJ, Daver NG, Alvarado Y, DiNardo CD, Ravandi F, Borthakur G, Bose P, Pemmaraju N, Naqvi K, Kornblau SM , Cortes JE, Kadia TM, Konopleva MY, Ohanian MN, Pierce SA, Gasior Y, Benton CB, Jain N, Takahashi K, Masarova L, Andreeff M, Estrov ZE, Kantarjian HM, Garcia-Manero G

In response to oxidative stress, cGAS activation via STING drives the expression of senescence-associated secretory phenotype (SASP) factors, including TNF-, IL-6, CXCL2, CXCL10, CCL3, and CCL5

Analyses were weighted to represent the civilian United States population

However, the direct and powerful delivery method comes with increased risks: Skin Discoloration: Some individuals may develop a rash