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Interim data demonstrated that the regimen was generally well tolerated, with most treatment-related adverse events limited to mild injection-site reactions and flu-like symptoms, and only two grade 3 events were reported (self-limiting fever and pembrolizumab-associated colitis)

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After consideration of public comments, we are finalizing the proposed prepaid shared savings application procedures under 425.640(c) with modifications to allow ACOs that renewed to enter an agreement period beginning on January 1, 2025, the option to elect to participate in prepaid shared savings starting with performance year 2026 without renewing again (as described and for the reasons explained elsewhere in section III.G.5