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For peptides like Epitalon to move from lab to clinic, the delivery method matters as much as the mechanism

doi: 10.1038/ncb3064

Glycocalyx degradation usually begins in the SIRS stage, when proinflammatory factors (TNF-, IL-1) activate endothelial cells and directly destroy the components of the glycocalyx (such as HS, HA) by activating MMPs [23]

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