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Methods: A Randomized Double-blind clinical trial, which included 20 patients for standard treatment (Group A: Prednisone 40 mg a day + Placebo (manufactured by the same laboratory with the same presentation and physical appearance) and 20 patients for combined treatment (Group B: Prednisone 40 mg per day + nanoemulsifiyied pomegranate seed oil rich in Omega 5 fatty acid (2 capsules of 0.64g each / day)

B12 is a pretty common vitamin deficiency, impacting up to 15 percent of the general population, per the NIH

doi: 10.1007/s00334-019-00731-8

In addition, DUSP12 deficiency induces myocardial hypertrophy, ventricular cavity enlargement, cardiac fibrosis, and cardiac dysfunction in HFD-fed mice, indicating that DUSP12 deficiency contributes to pathogenesis of diabetic cardiomyopathy

Platforms such as nanocages and dendrimers are particularly suitable for this purpose because they permit controlled release and surface customization