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DOI: 10.1016/j.freeradbiomed.2009.06.004 55

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Poor blood and lymph flow through fat tissue results in accumulation of fluid, cell waste material, proteins, cells and other metabolic products in the extracellular matrix (ECM) around adipocytes and other components of adipofascia, resulting in a hypoxic environment, especially in adipocytes furthest from their nutrient and oxygen sources

Sequential vs simultaneous administration Sequential approach: Start single peptide establishing baseline response and tolerability