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It is often described as a triple agonist because it targets GLP-1, GIP, and glucagon pathways

Powe DG, Akhtar G, Habashy HO, Abdel-Fatah T, Rakha EA, Green AR, Ellis IO

On the other hand, 20 patients (4 males and 16 females, with the age of 41.0 14.1 and 42.9 12.0 years old, respectively) with major depressive disorders were selected as the research objects, and it was found that L-theanine (250 mg/day) treatment for 8 weeks was safe and effective to significantly mitigate the symptoms of depression, anxiety, somnipathy, and cognitive disorder (67)

The final effect is a decreased risk of mitochondrial injury from fatty acid oxidation and a reduction of the production of acylcarnitines, which has been implicated in the development of insulin resistance