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All knockout strains had severe inflammation, disturbed crypt architecture, edema and increased inflammatory infiltration

In 2014, a paper in the *Journal of Pharmacology and Experimental Therapeutics* laid out dihexa's proposed mechanism that it works by binding hepatocyte growth factor and activating the c-Met system to build synapses

Data analysis was performed using Clampfit 10.2 software (Molecular Devices), and Mini- Analysis 6.0 software (Synaptosoft Inc

Stuart KA, Riordan SM, Lidder S, Crostella L, Williams R, Skouteris GG

Caspase inhibitors promote vestibular hair cell survival and function after aminoglycoside treatment in vivo