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Consequently, the numbers of commensal obligate anaerobes, including Clostridia and Bacteroidia , are reduced due to elevated oxygen concentrations in the intestinal mucosa, which increases the risk of enteric infection (Winter et al

They can carry DNA, RNA, proteins, and lipids and distribute them among cells

Remove that consistency and your results become unreliable, your side effect profile changes, and your ability to make informed decisions about dose adjustments disappears