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Description

Evidence-based therapies like cognitive behavioral therapy (CBT) and interpersonal therapy are effective on their own and work better in combination with medication for moderate-to-severe presentations (Cuijpers et al., World Psychiatry , 2014)

NNMT is overexpressed in adipose tissue and various cancer cell lines, and its inhibition has been studied as a strategy to increase intracellular NAD+ levels, enhance one-carbon metabolism, and reduce adipogenesis in preclinical models