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These disorders are associated with hemochromatosis which is the progressive and toxic accumulation of iron in parenchymatous organs

The two most used drugs for inducing ferroptosis, erastin, and Ras-selective lethal small molecules 3 (RSL3), were identified by the same research team in 2003 and 2008, respectively (Yang and Stockwell, 2008)

They may progress to be more severe in the course of time

Personalized nano-drug combinations should be customized based on CRC molecular typing and gut microbiota characteristics to achieve precision therapy

Exposure to oxidant stress damages the RBCs membrane and gives rise to Heinz bodies (denatured hemoglobin) formation