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Motawi TK, Sadik NAH, Hamed MA et al (2020) Potential therapeutic effects of antagonizing adenosine A2A receptor, curcumin and niacin in rotenone-induced Parkinsons disease mice model

A 2a receptor plays an anti-inflammatory role in specific cells and various inflammation models

The lipid hydroperoxide (ROOH) is unstable in the presence of iron or other metal catalysts because ROOH will participate in a Fenton reaction leading to the formation of reactive alkoxy radicals

The core chelation site relies on the imidazole ring of histidine and the side chain amino group of lysine to ensure the controlled release of copper ions