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In addition, dual inhibition of FGFR and VEGFR overcame resistance to anti-VEGF therapy and enhanced antitumor activity as well as antiangiogenesis activity in these models

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Combined triad-GSH metabolism model simulations: quinone metabolism and ROS production Following the parameterisation and sensitivity analysis, the triad model was expanded to include GS-H 2 Q adduct formation (quinone removal) and was combined with the glutathione metabolism model constructed by Reed et al