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MMNST often carry an inactivating mutation in the protein kinase A inhibitory subunit gene protein kinase cAMP-dependent type I regulatory subunit alpha (PRKAR1A) on chromosome 17p22-24, which acts as a tumor suppressor [3, 4]

Morsy, A., El-Zaiat, H., Saber, A., Anwer, M., & Sallam, S

Metabolic fluctuation between the oxidative and reductive phases is regulated as a function of the cell cycle with cell division strictly confined to the reductive phase in budding yeast (Tu et al., 2005)

As these points were only present in PLA and were not influential in the overall outcomes, all data points were retained in the analysis