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Hcy interacts with cysteine-825 residues situated on the pro-insulin receptor within the endoplasmic reticulum (ER), thereby disrupting the formation of initial disulfide bonds

Lactate dehydrogenase A (LDHA)-deficient CD4 T cells have impaired glycolytic function and produce less IFN, indicating a functional defect

After correction using the ComBat method ( Supplementary Figures 1C, D ), dataset differences among samples significantly decreased, and the clustering structure of RA and normal control groups in principal component space became clearer, indicating that the data processing workflow effectively enhanced data quality and the reliability of subsequent analyses

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Barberine has also shown neuroprotective effects via elevating the mitochondrial membrane potential (MMP) (Moneim, 2015)