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In addition to weight loss benefits, GLP-1 therapy is an effective treatment for type 2 diabetes

Also studied was the combined application of N G -nitro-L-arginine methylester (L-NAME) (5 mg/kg i.v.), a competitive inhibitor of endothelium nitric oxide (NO)-generation and the NO-precursor L-arginine (200 mg/kg i.v.) (D-arginine was ineffective)

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Unlike short peptides, long peptides need to be processed by APCs before they can be presented on MHC molecules

But those trials were small (approximately 300 subjects total across phases), short (up to 24 weeks), and used a route of administration that likely delivered minimal systemic exposure