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doi: 10.1194/jlr.P055418 116 VidelaLAFernndezVVargasRCornejoPTapiaGVarelaNet al

All indices of time- and frequency- domain of HRV at M3 were significantly increased when compared with baseline values)." They conclude that "The findings of this study imply that long-term treatment with ivabradine at a dose of 1.0 mg/kg twice daily in dogs with asymptomatic DMVD stage B2 decreased the HR, BP, MVO2 and improves HRV