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Off-period (weeks 12+) : 4 to 6 weeks off lets baseline NNMT activity reset before the next cycle

Trans Oncol (2020) 13(8):100785

Glucagon-like peptide-1 receptor agonists in the treatment of idiopathic inflammatory myopathy: from mechanisms of action to clinical applications

LiE = log(IC50) clogP (clogP calculated by ChemDraw). Surface plasmon resonance (SPR) analysis further confirmed the direct binding of AB4 to RAGE, with a moderate affinity (KD = 3.86 M)