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The main safety issue was brain swelling and bleeding, a problem common to all plaque-targeting drugs

Paul Offit, a member of the FDA's advisory committee, said data based on mice studies is not sufficient to justify authorizing the new boosters

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Our present results indicate that treatment with a heavy-chain anti-CD38 antibody selectively targeting the ectoenzyme domain, but not with an anti-CD38 antibody that does not block ectoenzyme, prevented bleomycin-induced weight loss, skin fibrosis and architectural remodeling in the lung, accompanied by reduced collagen deposition and significant improvement of pulmonary functions

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