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Description

Future studies should focus on the relationship between pyroptosis and TIME in GBM

Ubiquitin-specific peptidase 53 inhibits the occurrence and development of clear cell renal cell carcinoma through NF-B pathway inactivation

Preliminary antitumoral activity has been presented at ASCO 2024, with an ORR of 19% and a median DoR of 11.3 months in all NSCLC subtypes (n=116) and 31% and 11.6 months, respectively, in non-squamous taxane-nave NSCLC (n=42)

Most likely lysosomotropic compounds and arsenic share a similar course of action, which starts with lysosomal dysfunction, then autophagy blockage, ultimately leading to Nrf2 activation mediated by SQSTM1/p62