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EPR (electron paramagnetic resonance) spectroscopy experiments have demonstrated that peroxynitrite oxidizes BH4 to the (non-protonated) BH3 (trihydrobiopterin) radical, and then to BH2, with a rate constant estimated to be 6 10 3 M 1 s 1 , several-fold higher than reactions between peroxynitrite and ascorbate, glutathione or thiol groups [68]

This cascade effectively prevented mitochondrial membrane potential collapse and hepatocyte apoptosis (Yin Y

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mSystems 6:e00443-21

Circulating precursor CCR7loPD-1hi CXCR5+ CD4+ T cells indicate tfh cell activity and promote antibody responses upon antigen reexposure