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doi: 10.1016/j.cmet.2020.12.007 37 ShimadaKSkoutaRKaplanAYangWSHayanoMDixonSJet al

Antibody-drug conjugate overview: a state-of-the-art manufacturing process and control strategy

Here, DNA lesions characteristic of oxidised purine and pyrimidine bases were identified with further analysis revealing intracellular ROS associated with superoxide, singlet oxygen, and hydroxyl radicals chiefly mediate lesion formation

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