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[DOI] [PubMed] [Google Scholar] 114.Kumar, S

A: Some studies suggest activity when administered orally or via injection in animal models, but this is still under investigation and not clinically validated

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In contrast, when tissue folate or cobalamin stores are intact (Silberberg et al, 1997) or in the case of an alteration of the transsulfuration pathway dependent on vitamin B 6 deficiency or on heterozygosity for a CBS defect (Bostom et al, 1995a), an excessive methionine supply might lead to an important elevation of plasma homocysteine

Abbreviations AS: artesunate CI: combination index DMSO: dimethylsulfoxide iFBS: heat inactivated fetal bovine serum NAC: N-acetylcysteine NTS: newly transformed schistosomula PI: propidium iodide PZQ: praziquantel RESV: resveratrol TEM: transmission electron microscopy References Steinmann P, Keiser J, Bos R, Tanner M, Utzinger J