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However, this approach is notably less effective for individuals with chronic forms of thiamine deficiency-related disorders involving encephalopathies (see the section Wernicke Encephalopathy) (113) or TPK1 deficiencies

doi: 10.1073/pnas.081082098 5 DeLeveL

M., Zhang, L., Ye, Z.-W., Zhang, J., Tew, K

A.YakubovE.EngelhornT.DoerflerA.BuchfelderM.et al (2016a)

In terms of their susceptibility to apoptotic cell death, dopamine has been shown to be pro-apoptotic therefore a reduction in its levels could be protective to the developing amacrine cells 43,44