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Resistance rates to biologic agents for CD treatment reach 3040%

Of note, among the elevated inflammatory mediators, the blood IL-6 level is highly correlated with the disease mortality when COVID-19 survivors and non-survivors are compared [1, 11], suggesting that fatal COVID-19 is characterized as a cytokine release syndrome (CRS) that is induced by a cytokine storm with high mortality [12,13,14]

Abbreviations LD: Lyme disease Bb: Borrelia burgdorferi LC-MS/MS: Liquid chromatography-tandem mass spectrometry BSK-H: Barbour-Stoenner-Kelly-H RT: Room temperature NSAF: Normalized spectral abundance factors SDS: Sodium dodecyl sulfate DTT: Dithiothreitol IgG: Immunoglobulin G Serpin: Serine protease inhibitor TIL: Trypsin inhibitor-like MP: Metalloprotease AMP: Antimicrobial peptides TSP: Tick-specific proteins of unknown function RNAi: RNA interference PAR: Protease-activated receptors NPC: Niemann-Pick type C ML: MD-2-related lipid-recognition GRP: Glycine rich proteins ECM: Extracellular matrix CS: Cytoskeletal ROS: Reactive oxygen species H 2 O 2 : Hydrogen peroxide NET: Neutrophil extracellular traps ATP: Adenine triphosphate NADH: Nicotinamide adenine dinucleotide hydride HSP: Heat shock protein CRT: Calreticulin IGFBP-rP: Insulin growth factor binding proteins-related proteins OspC: Outer surface protein C ELISA: Enzyme-linked immunosorbent assay References Rosenberg R, Lindsey NP, Fischer M, Gregory CJ, Hinckley AF, Mead PS, et al

Fukumura, D

Close monitoring by a dermatologist is required