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Many nanotechnology-based delivery systems are still in the proof-of-concept stage, even for drugs that are already approved for human use via other routes (or vehicles based on materials already approved for other uses)

Depletion or overexpression of RABGAP1 caused mistrafficking and misprocessing of endogenous APP in human and rodent neurons

GordonBSKaziAAColemanCSDennisMDChauVJeffersonLSet al

Diabetes 69(4):508-16 2020 PMC7085249 Gomes Kjerulf D, Wang S, Omer M, Pathak A, Subramanian S, Han CY, Tang C, den Hartigh LJ, Shao B, Chait A

Analysis of tumor PD-L1 expression and biomarkers in relation to clinical activity in patients (pts) with deficient DNA mismatch repair (dMMR)/high microsatellite instability (MSI-H) metastatic colorectal cancer (mCRC) treated with nivolumab (NIVO) 1 ipilimumab (IPI): CheckMate 142