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Physiol Rev 100(3):12911346 Rodrigues CM, Sol S, Silva RF, Brites D (2002) Aging confers different sensitivity to the neurotoxic properties of unconjugated bilirubin

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Clinical and postmortem studies consistently demonstrate reduced BDNF expression and diminished neurogenic capacity in individuals with depression, while effective antidepressant treatments, including SSRIs, SNRIs, and electroconvulsive therapy, restore neurogenesis and promote neuronal maturation