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In older children or adults it may be considered if there are clinical symptoms suggestive of carnitine deficiency (hypotonia, lethargy), a significant decrease in the serum free carnitine levels, an impairment in hepatic function tests, or hyperammonaemia, even in the absence of VHE

He M-D, Xu S-C, Lu Y-H, Li L, Zhong M, Zhang Y-W, et al

( b ) Immunoblot of ACLY and ACSS2

PubMed PMID: 23543271 Kanakry JA, Ambinder RF

Regarding expression and activity, the knowledge about the regulation of carriers and enzymes that modulate -oxidation in cancer cells is of extreme interest since their inhibition may significantly affect the tumorigenic potential even in the presence of compensatory metabolic pathways