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Analysis of four mutants, viz E398A, E398D, E398R, and E398Q of BlGGT, suggested that the C-terminal of the large subunit was indeed critical for autoprocessing of BlGGT ( in vitro incubation

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In CCH models, they attenuate astrocyte activation and improve cognition, showing synergy with STAT3 inhibitors (278)

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Isoxazole 1 and 2 are highly selective inhibitors of Cn Acs1 The isoxazole Cn Acs1 inhibitors are structurally distinct from other fungal, human, and Plasmodium falciparum Acs inhibitors reported in the literature 11,17,18,34,35