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FTO level is upregulated in PD model, while FTO silencing alleviates cell ferroptosis

The principal cause of ferroptosis is linked to the peroxidation of PUFAs (Gan, 2022) and PE (Lei et al., 2019)

An in vitro experiment has revealed that ferroptosis inhibitor FSP1 or GPX4 overexpression protects CD8 T cells from ferroptosis, while the utilization of GPX4 inhibitors significantly enhances the sensitivity of T cells to ferroptosis (71)

Results: Among 12,317 patients identified with HDV or HBV only, 756 met all inclusion criteria (HDV, n=126

Often, the next test is serum methylmalonic acid (MMA), a functional marker of B12 deficiency that's produced when there's not enough active vitamin B12 present