5 amino 1mq clinical trial human 5-Amino-1MQ Benefits, Safety, and Uses 5-Amino-1MQ NNMT Inhibitor for Research

Administration: Subcutaneous Injection

The clinical evidence overwhelmingly favors semaglutide for meaningful fat reduction, but the nearly nonexistent side effect profile of AOD 9604 gives it a unique position for specific use cases

Sports 33, e159e165

Le Roith D, Kim H, Fernandez AM, Accili D

PMID: 29155147): 5-Amino-1MQ showed NNMT selectivity with IC50 of 1.2 microM Reduced body weight and white adipose mass in diet-induced obese mice over 11 days No effect on food intake, suggesting metabolic rather than appetitive mechanism Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice , published in Scientific Reports (Dimet-Wiley AL et al., 2024