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Science 357(6357):eaaf4382

The copper component is well-tolerated at recommended doses but should be monitored in long-term use

Moreover, FA injection induced severe inflammation, indicated by increased release of pro-inflammatory cytokines tumor necrosis factor (TNF)- and IL-1, as well as infiltration of macrophage, which can be alleviated by LA supplementation

Additionally, a one-year placebo-controlled trial in adults aged 65 years and older found that daily supplementation with a multivitamin/mineral did not benefit cognitive performance on a verbal fluency test an assessment in which participants were asked to list words starting with a certain letter in a designated time period (135)