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12,19,20 Fentanyl and hydromorphone are suitable alternatives to morphine secondary to their ease of titration when given parenterally

Their presentation is different and the classic triad is depression, aggression, and dementia

Surgery for abdominothoracic metastatic disease

Overall, GWAS have either failed to identify genes responsible for bipolar disorder, due to relatively small individual contributions, inadequate sample size, or disease heterogeneity (21, 30), or they have identified genes involved in housekeeping functions, such as translation, transcription, energy conversion, and metabolism (32)

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