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692,693 Mutations in key TCA cycle enzymes, such as SDH, fumarate hydratase, and IDH, lead to TCA cycle dysfunction and mitochondrial metabolic defects across various human cancers

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Abstract Acetaminophen (APAP) overdose is the leading cause of drug-induced liver injury worldwide, and mitochondrial oxidative stress is considered the major event responsible for APAP-associated liver injury (ALI)

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Research applications require consideration of the peptide's selectivity mechanisms and potential off-target effects, while the well-characterized mechanism provides foundation for power calculations and experimental planning in senescence research applications across diverse biological systems and disease models