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Decreased GSH leads to a cascade of events, including an inability to mitigate oxidative stress, a subsequent increase in the release of cytokines IL-6 and TGF-, both of which are shown to further decrease GSH synthesis, and an increase in platelet activation, contributing to microclot formation

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doi: 10.1016/j.biopha.2018.03.142 121 MaJDJingJWangJWYanTLiQHMoYQet al

Tait, D

The ensuing chronic obstructive pulmonary pathology ultimately culminates in irreversible airflow obstruction, potentially escalating to chronic respiratory failure and mortality (205, 206)