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Furthermore, the heterogeneity of the immune microenvironment further limits therapeutic efficacy: competitive uptake of glutamine by tumor cells via SLC38A2 significantly impairs the antigen-presenting capacity of dendritic cells (33), while MDSCs and TAMs exhibit enhanced immunosuppressive activity under glutamine-deficient conditions (79)

136 Prousky, J

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Methods Study population The AGRE was created by Cure Autism Now and the Human Biological Data Exchange to advance genetic research in autism spectrum disorders by consolidating large numbers of families into one collection (www.agre.org

We provide evidence that the disease-promoting effect of eosinophils is related to their superior uptake of glucose and the consecutive inhibition of Th1 effector cell function