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This controversy becomes evident under specific conditions, such as the effects of hypobaric hypoxia on bone

doi: 10.3389/fmicb.2022.838164 Received 07 January 2022 Accepted 09 June 2022 Published 04 July 2022 Volume 13 - 2022 Edited by Weiqi He, Soochow University, China Reviewed by Li HuaShan, Soochow University, China

The discovery of enzymes that reverse the methylation of lysines and arginines challenges our current thinking on the unique nature of histone methylation, and substantially increases the complexity of histone modification pathways