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Neuropathology 23 , 345350 (2003)

Gariani K, Menzies KJ, Ryu D, Wegner CJ, Wang X, Ropelle ER, et al

However, when Cys 129 residue of PTPN22 is mutated, the disulfide bond cannot form and the enzyme is exposed by oxidation, resulting in inactivation (93)