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The term of oncometabolites refers to intermediates of metabolism that abnormally accumulate in cancer cells upstream or downstream of metabolic defects, often through loss-of-function or gain-of function mutations, respectively, in genes encoding the corresponding enzymes (177)

Calcium Calcium ions are important intracellular signals that regulate a number of physiological processes, including neuronal gene expression, neuronal secretion of neurotransmitters into synapses, and synaptic plasticity (reviewed in 60)

All human studies were conducted in accordance with the principles of the Declaration of Helsinki

Among the agents that mediate their effects through S -glutathionylation, NOV-002 has been most extensively studied, with a phase III trial (NCT00347412) completed in advanced NSCLC [104], and data available from phase II trials in breast and ovarian cancers [105]

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